Let’s Talk About The Gut Skin Axis

Nuala Mcbride


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Let’s Talk About The Gut Skin Axis

Most people’s teenage years were plagued with the dreaded acne. Many of us grew out of these phases, but you still might experience the odd flare up or two.

Growing up I always looked to my skincare routine to find the harmony of creams, serums, face washes etc to get my skin looking radiant. However, I wasn’t looking all in the right places for the answer to my skin problems. Acne can stem from many factors beyond your skincare routine, such as stress, hormones, metabolism and genes. But the most interesting area (to me) is the gut skin axis. The gut-skin axis is concerned with the impact your gut microbiome has on your skin.

There are many emerging studies looking into this area. Delving into PubMed with the keywords “acne gut health” the first two studies appeared in 2014. By 2019 there were 7 published that year and by 2023 there were 13 published that year. The common finding in these studies is that there is a link between the intestinal microbiota and skin homeostasis, a communication mainly established by modifying the immune system. This is a new field so to date there is no consensus on the exact mechanisms involved with this. It’s suspected that it is rooted in the inflammatory immune response.

The Gut-Skin Axis

A women with head floating in the water

The gut-skin axis is a bidirectional communication system that links the gastrointestinal tract with the skin. This intricate relationship relies on several mechanisms, primarily involving the immune system, the gut microbiome, and the endocrine system.

  • Immune System Harmony: Did you know that the gut is home to around 70% of the body’s immune system? When the gut is in a state of balance (homeostasis), it helps regulate the immune response and prevent inflammatory reactions. Disruptions in gut health, such as leaky gut syndrome, can lead to systemic inflammation, triggering skin conditions like acne, psoriasis, and eczema.
  • Microbial Matters: The gut microbiome, a complex community of trillions of microorganisms, plays a pivotal role in both gut and skin health. A healthy gut microbiome supports immune function and nutrient absorption, while also influencing the production of certain metabolites. These metabolites, such as short-chain fatty acids (SCFAs), can exert anti-inflammatory and anti-microbial effects, contributing to the overall health of the skin.
  • Hormonal Influence: The gut can modulate hormone levels, including those associated with skin health, such as insulin-like growth factor 1 (IGF-1) and sex hormones. Dysregulation in these hormones can lead to increased sebum production, a key factor in the development of acne.


Common Skin Conditions and Gut Health

  • Acne: Studies have indicated a potential link between gut dysbiosis (imbalance in gut microbiota) and the development of acne. High-sugar and high-glycemic diets can disrupt gut health and exacerbate acne by increasing insulin levels and promoting inflammation.
  • Eczema: Emerging research suggests that an imbalanced gut microbiome may contribute to the development of eczema. Probiotic supplementation has shown promise in reducing the severity of symptoms in some individuals with eczema.
  • Psoriasis: Psoriasis, characterized by chronic skin inflammation, may also have connections to gut health. Dysbiosis and inflammation in the gut could potentially trigger or worsen psoriasis symptoms.


Promoting Gut Health for Radiant Skin

There’s lots that you can do to support your gut health and subsequently your skin. Here’s some ideas:

flowers balancing on an arm

  • Dietary Choices: Consuming a diet rich in fiber, antioxidants, and probiotics can support a diverse and healthy gut microbiome. Foods like yogurt, kefir, sauerkraut, and fiber-rich fruits and vegetables promote gut health.
  • Probiotics and Prebiotics: Probiotic supplements and prebiotic-rich foods nourish beneficial gut bacteria. These can help restore gut balance and improve skin conditions.
  • Stress Management: Chronic stress can negatively impact gut health and exacerbate skin conditions. Incorporating stress-reduction techniques such as meditation, yoga, or mindfulness can contribute to overall well-being.



The intricate connection between gut health and skin is an exciting frontier in dermatology and gastroenterology. While the gut-skin axis is still being explored, emerging evidence suggests that a balanced gut microbiome, a healthy immune system, and mindful dietary choices can lead to clearer, more radiant skin. Further research will undoubtedly uncover new insights into how our internal health profoundly influences our external appearance, redefining our approach to skincare and wellness.

As our understanding of the gut-skin connection grows, it becomes increasingly clear that maintaining a harmonious gut environment is not only beneficial for digestive health; but may also hold the key to unlocking the secret to vibrant and healthy skin.


If you feel your skin isn’t where you want it to be, then drop me an email to see how I can help – info@thenutritiousway.net

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Hi! I'm Nuala

Thanks for taking a look at my blog! It’s where I write about all my favourite topics in Nutrition.
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